| Myo-inositol + D-chiro inositol (40:1) | 2g myo-inositol, twice daily | Insulin sensitivity, ovulation, androgens | Strong | The best-supported supplement in PCOS. Give it three months. Generally considered safe when trying to conceive, but confirm with your doctor. |
| Vitamin D3 | Dose to your lab result — often 1,000–4,000 IU | Insulin sensitivity, cycle regularity, mood | Strong | Only useful if you're low, and most people are. Test rather than guess. Take with a meal containing fat. |
| Omega-3 (EPA/DHA) | 1–2g combined EPA+DHA | Inflammation, triglycerides, androgens | Moderate | Fatty fish twice a week does much the same job. |
| Magnesium glycinate | 200–400mg at night | Sleep, cramps, insulin, premenstrual mood | Moderate | Glycinate for sleep; citrate if constipation is the issue. Oxide is mostly wasted. |
| N-acetylcysteine (NAC) | 600mg, two to three times daily | Insulin sensitivity, ovulation | Moderate | Compares reasonably with metformin in several trials, with fewer stomach complaints. |
| Zinc | 15–30mg with food | Acne, unwanted hair, hair shedding | Moderate | Don't run high doses long-term — it depletes copper. |
| Spearmint tea | Two cups daily | Free testosterone, facial hair | Emerging | Small studies, modest effect, essentially no downside. Pleasant way to hit the target. |
| Berberine | 500mg, two to three times daily | Insulin resistance, lipids | Moderate | Stop before trying to conceive, and don't use while pregnant or nursing. Interacts with a long list of medications — clear it with a pharmacist first. |
| Prenatal with methylfolate | Daily | Baseline nutrient cover | Strong | Worth starting three months before any attempt at conceiving, not at a positive test. |